Toxicology

Sodium Nitrite Negatively Affects Reproductive Ability and Offspring Survival in Mice

NaNO2 is a chemical coming from industries and used as food additive to prevent botulism (a type of poisoning caused by toxin from a type of anaerobic bacteria known as Clostridium botulinum) and accelerate glossiness (to have smooth, silk-like surface/skin).

A recent study by a group of seven researchers from People’s Republic of China published in Toxicology Journal  researched on the effects of reproductive ability of female mice by NaNO2. They also studied the effects of the oocyte morphology, spindle chromosome dynamics and mitochondrial distribution etc.

These researcher’s result clearly showed that treatment of NaNO2 decreased oocyte number, impaired polar body extrusion, and increased zona pellucida thickness in oocytes. Further, this chemical also disrupted MII spindle integrity, the distribution of mitochondria was abnormal, ATP contents were decreased and many more.

The treatment by NaNO2 mice decreased offspring numbers and survival rate.

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Sohail Anjum

Sohail Anjum completed his undergraduate degree in Zoology from University of Malakand in September 2019. He is a young researcher in Ecology. He has also worked with IUCN as a Reviewer of Proposals for IUCN Congress 2020.

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